Determination of Constituents of Extract of Celtis tournefortii Lam. by LC-MS/MS, Investigation of Enzyme Inhibition, Antimicrobial and Anticancer Effects

Phytochemicals found in extracts obtained from plants are very important bioactive constituents. In this study, phytochemicals extract content Celtis tournefortii .Lam. tree (CT) leaves were determined by a LC-MS method. The constituents with the major concentrations was rutin (2479.89 µg ml-1), coumarin (1241.68 biochanin A (1026.42 shikimic acid (477.32 chlorogenic (300.76 ml-1). suppressive effects of CT on growth pathogenic strains studied microdilution It observed that it caused suppression concentration range 2.00-8.00 ml-1. inhibition acetyl cholinesterase and glutathione-S transferase enzyme activities investigated, 50% inhibitory values activity to be 13.58 13.86, respectively. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay method, cell viability leaf healthy skin fibroblast cells as well ovarian, colon brain cancer cells. they created 42%, 4.27%, 14.29% cells,